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2 edition of Bioassay of 3-nitro-p-acetophenetide for possible carcinogenicity found in the catalog.

Bioassay of 3-nitro-p-acetophenetide for possible carcinogenicity

National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

Bioassay of 3-nitro-p-acetophenetide for possible carcinogenicity

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Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health in Bethesda, Md .
Written in English

    Subjects:
  • Carcinogens.,
  • Phenacetin -- Toxicology.

  • Edition Notes

    StatementCarcinogenesis Testing Program, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of Health.
    SeriesDHEW publication -- no. (NIH) 79-1388, Carcinogenesis technical report series -- no. 133
    ContributionsNational Institutes of Health (U.S.)
    The Physical Object
    Paginationix, 50 p. :
    Number of Pages50
    ID Numbers
    Open LibraryOL22412354M

      The following files are in this category, out of total. National Institutes of Health, National Cancer Institute, Rockville Pike, Bethesda, Montgomery County, MD HABS MD,BETH,3Btif 5, × 4,; MB. Surgeon General breaks ground for cancer institute. Bioaccumulation Estimates from Log Kow (BCFWIN v): Log BCF from regression-based method = (BCF = ) log Kow used: (expkow database) Volatilization from Water: Henry LC: E atm-m3/mole (estimated by Group SAR Method) Half-Life from Model River: hours ( days) Half-Life from Model Lake: hours ( days. 2-Butene, 2-nitro-. Molecular weight: Download the identifier in a file. The 3d structure may be viewed using Java or Javascript. Permanent link for this species. Use this link for bookmarking this species for future reference.


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Bioassay of 3-nitro-p-acetophenetide for possible carcinogenicity by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Download PDF EPUB FB2

A bioassay for possible carcinogenicity of 3-nitro-p-acetophene­ tide was conducted using Fischer rats and B6C3F1 mice. 3-Nitro­ p-acetophenetide was administere idn the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species, with the exception of low dose male mice, of which there were A bioassay for possible carcinogenicity of 3-nitro-p-acetophenetide was conducted using Fischer rats and B6C3F1 mice.

3-Nitro-p-acetophenetide was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species, with the exception of low dose male mice, of which there were 1.

Author(s): Mason Research Institute. ; National Institutes of Health (U. ); Carcinogenesis Testing Program (U. ) Title(s): Bioassay of 3-nitro-p-acetophenetide for possible carcinogenicity.

3-Nitro-p-acetophenetide: Target Organs and Levels of Evidence for TR Bioassay of 3-Nitro-p-Acetophenetide for Possible Carcinogenicity (CASRN ) Chemical (Study Title). Evaluation of the Chronic Toxicity and Carcinogenicity of 3-Nitro-p-acetophenetide () in Male B6C3F1 Mice Exposed via Dosed Feed.

Individual Animal Data. P14 - Male Individual Animal Pathology Data. Male Individual Animal Pathology Data Neoplastic. Male Individual Animal Pathology Data Non Neoplastic. A bioassay for possible carcinogenicity of 3-nitro-p-acetophenetide was conducted using Fischer rats and B6C3F1 mice.

3-Nitro-p-acetophenetide was admin in the feed, at either of two concn, to groups of 50 male and 50 female animals of each species, with the exception of low dose male mice, of which there were Molecular Formula: C10H12N2O4.

Bioassay of 3-nitro-p-acetophenetide for possible carcinogenicity. National Toxicology Program Natl Cancer Inst Carcinog Tech Rep Ser,01 Jan The ingredient 3-nitro-p-hydroxethylaminophenol is used in oxidative hair colouring products at a maximum on-head concentration of 3, after mixing the hair dye formulation with hydrogen peroxide typically in proportions.

3-Nitro-p-hydroxethylaminophenol is also used in semi-permanent hair colouring products at a maximum concentration of. - UOIPFPSGIAWJAQ-UHFFFAOYSA-N - 3'-Nitro-p-acetophenetidide - Similar structures search, synonyms, formulas, resource links, and other chemical information.

) Give the entire mechanism for 3-nitrobenzaldehyde and acetophenone to make 3-nitrochalcone. NaOH was the base used in this reaction.

) Draw the entire mechanism for this reaction if it was catalyzed by an acid instead of the base NaOH. The Hazard fields include special hazard alerts air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible information in CAMEO Chemicals comes from a variety of data sources.

Bioassay of 5-nitroacenaphthene for possible carcinogenicity (CAS No. National Toxicology Program. A bioassay of 5-nitroacenaphthene for possible carcinogenicity was conducted using Fischer rats and B6C3F1 mice. 5-Nitroacenaphthene was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female.

Predicted data is generated using the US Environmental Protection Agencys EPISuite. Log Octanol-Water Partition Coef (SRC): Log Kow (KOWWIN v estimate) Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v): Boiling Pt (deg C): (Adapted Stein Brown method) Melting Pt (deg C): (Mean or Weighted MP) VP(mm Hg,25 deg C): E (Modified Grain.

These differential effects, and the issue of the "maximum tolerated dose" for testing, stimu- late the greatest controversies about extrapolat- ing rodent bioassay results to human carcinogen Correspondence: Dr.

Raymond W. Tennant, Ph.Experi- mental Carcinogenesis and Mutagenesis Branch, National In- stitute of Environmental Health Sciences. USA USA USA USA US A US A US A US A US A US A US A US A US A US A US A US A Authority US United States Prior art keywords para ortho nitroacetophenone oxime mixture Prior art date Legal status (The legal status is an assumption and is not a legal conclusion.

Sample Handling and Preservation Analysis should be made as soon as possible. If analysis can be made within 24 hours, the sample should be preserved by refrigeration at 4°C.

When samples must be stored for more than 24 hours, they should be preserved with sulfuric acid (2 mL conc. H 2SO 4 per liter) and refrigeration.

Interferences. 4-AminoNitrophenol, 4-HydroxypropylaminoNitrophenol and 3-Nitro-p-Hydroxyethylaminophenol may be used hair dyes marketed in the Europe.

After dilution with hydrogen peroxide, these ingredients are permitted at maximum concentration ofand 3 for 4-AminoNitrophenol, 4-HydroxypropylaminoNitrophenol and 3-Nitro-p. Hydrating this alkyne in the presence of mercury (II) salt and sulfuric acid will result in the obtention of your desired compound.

In another method, we take p-chlorobenzene and react it with the anion of nitroethane and then, using Nef reaction, we convert the nitro group to a ketone. In conclusion, your method is not really feasible due to. 3-methylnitrophenylbutanone - C11H13NO3, synthesis, structure, density, melting point, boiling point.

Product name: p-Nitro Acetophenone CAS-No. : Relevant identified uses of the substance or mixture and uses advised against Identified uses: Laboratorychemicals, Industrial for professional use only. Details of the supplier of the safety data sheet Company: Central Drug House (P) Ltd 728 Vardaan House New Delhi INDIA.

Introduction: In the first part of this experiment N-acetylNitro-p-toluidine is formed by reacting Nitric Acid with N-acetyl-p-toluidine at 40 C. The product is expected to be a yellow crystal that has an orange filtrate. This product is then used to form 2-Nitro-p-toluidine by reacting the product with potassium hydroxide, ethanol and water in a reflux.

Buy 3-Nitroacetamidophenol, a biochemical for proteomics research, from Santa Cruz. Molecular Formula: C8H8N2O4, Molecular Weight: A bioassay of 3-nitropropionic acid (95 pure) for possible carcinogenicity was conducted by admin the test chemical by gavage to Fischer rats and B6C3F1 mice.

Groups of 50 rats and 50 mice of each sex were admin 3-nitropropionic acid at one of the following doses by gavage 5 dayswk. Synthesis Reference(s): The Journal of Organic Chemistry, 47, p.DOI: joa Physical Properties.

Mutation Research, () Elsevier Science Publishers B. 91 ADONIS S MUTREV Definitive relationships among chemical structure, carcinogenicity and mutagenicity for chemicals tested by the U. NTP John Ashby a and Raymond W. Tennant b a ICI Central Toxicology Laboratory, Alderley Park, Cheshire.

BIOASSAY OF 2-METHYL-l-NITROANTHRAQUINONE. FOR POSSIBLE CARCINOGENICITY. CAS No. NCI-CG-TR U. DEPARTMEN OTF HEALTH, EDUCATION AND WELFAR, E Public Healt Servich e National Institute of Healts h. No data available(3'-Nitroacetophenone) Respiratoryor skin sensitisation No data available(3'-Nitroacetophenone) Germ cell mutagenicity No data available(3'-Nitroacetophenone) Carcinogenicity IARC: No component of this product present at levels greater than or equal to is identified as probable, possible or confirmed human carcinogen by IARC.

A Third Type of Carcinogen Was Found in Blood Pressure Medication, FDA Says. are posting a tidy gain as of p. EDT Wednesday. In a note. Step 1-Synthesis of 3-nitrobenzoic acid NaOCI OH NO2 NO2 Mechanism for conversion ofm-nitroacetophenone to m-nitrobenzoic acid - An example of the Haloform Reaction.

An I 3 solution was first made by creating a 3 by weight iodine solution and mixing it with acetic acid in a ratio by volume respectively. A recorded weight of SNAP-HPAMAM was first pre-treated with a 5 acidified sulfanilamide solution to react with any unreacted sodium nitrite that could still be present from the nitrosation step.

Part I: Carcinogenicity of 1,2,3,4-diepoxybutane, Res. Rep. Health Eff. Inst. (92) () [] IARC Monographs on the Evaluation of Carcinogenic Risks to Humans vol.

46 (). Diesel and Gasoline Engine Exhausts and Some Nitroarenes, pages. The biosynthetic pathway for the cyanogenic glucoside dhurrin derived from tyrosine has been studied in vitro by using [18O]oxygen and a microsomal enzyme system obtained from etiolated sorghum seedlings.

The products formed were purified by HPLC and TLC, and the incorporation of [18O]oxygen was monitored by mass spectrometry. In the presence of NADPH and [18O]dioxygen, L-tyrosine is.

Synthesis of P-Nitro Acetanilide. In this experiment, we convert acetanilide to p-nitroacetanilide. The mechanism for the nitration is that of electrophilic aromatic substitution.

The nitronium ion is directed to the positions ortho and para to the acetamido (-NHCOCH3) group. This occurs because the resonance electron-releasing effect of that.

Table 9 lists nitro derivatives of aniline. preference in reduction is given to the nitro group ortho to the amino group.

(2,4-dinitroaniline, 2,6-dinitroaniline, 3,5-dinitroaniline) even in presence of other alkoxy or alkyl substituents, the nitro group ortho to the amino group is only reduced. (4,6-dinitro-o-toluidine, 4,6-dinitro-o-anisidine. 2-nitro-p-phenetidine.

The Substance identity section is calculated from substance identification information from all ECHA databases. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number andor the molecular and structural formulas.

Some substance identifiers may have been. 3-Nitrobenzanthrone (3-nitro-7H-benz[de]anthracenone) is a chemical compound emitted in diesel exhaust; it is a potent carcinogen. It produced the highest score ever reported in the Ames test, a standard measure of the cancer-causing potential of toxic chemicals, far greater than the previous known strongest (1,8-dinitropyrene, which is also found in diesel exhaust).

Nitro compounds can be prepared in a number of ways, including the direct substitution of hydrocarbons with nitric acid, () RH HONO 2 RNO 2 H 2 O. by displacement reactions with nitrite ions, () RX NO 2 RNO 2 X.

and by oxidation of primary amines, ( antibacterial and antifungal activity. The most striking feature has been the activity of Cu-furazolidone complex, it was found to be uniformly active against all the strains of bacteria and fungi under study.

3 A2H3 Figure condensation reaction with (5-Nitrofuraldehyde) with aminoguanidine bicarbonate produced a hydrozone with a byproduct of water.

The product is light yellow; it softens at 74° and melts at 7678°. The total yield is 45 g. (55 per cent of the theoretical amount) (Note 11). Notes. The only flask found suitable for this preparation is the 1-l. wide-mouthed Erlenmeyer.

A large flask is necessary to ensure rapid cooling. Combination therapy with angiotensin converting enzyme (ACE) inhibitors and nitrates in patients with heart failure may obviate the need for concomitant hydralazine, reduce nitrate tolerance and improve patient outcomes.

These topics are the focus of a continuing medical education (CME) activity published June 3 in the JACC: Heart Failure. Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen. Component CAS-No IARC NTP ACGIH OSHA Mexico p-Aminoacetophenone Not listed Not listed Not listed Not listed Not listed Mutagenic Effects No information available Reproductive Effects No information available.5-Nitropropoxyaniline, also known as P and Ultrasüss, is about 4, times the intensity of sucrose (hence its alternate name, P).

It is an orange solid that is only slightly soluble in water. It is stable in boiling water and dilute acids. 5-Nitropropoxyaniline was once used as an artificial sweetener but has been banned in the United States because of its possible toxicity.

It seems 3-nitro 4-chloro benzene 1-sulfonic acid can be made directly from chlorobenzene in almost quantitative yield (96%), at least using % sulfuric. Curious what reaction conditions and yield for the substitution of the chloro group by reaction with strong ammonia, ammonia/ethanol or urea, like Boffis suggested, would be (if possible at.